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Symbol Name ID |
Nras
neuroblastoma ras oncogene MGI:97376 |
| Darker colors indicate more annotations |
| Human Phenotypes | Decreased lymphocyte apoptosis |
Increased circulating IgA level |
Increased circulating IgG level |
Decreased circulating antibody level |
Increased circulating antibody level |
Paraproteinemia |
Neutropenia |
Lymphocytosis |
Monocytosis |
Leukemia |
Acute lymphoblastic leukemia |
T-cell acute lymphoblastic leukemias |
Acute myeloid leukemia |
Juvenile myelomonocytic leukemia |
Autoimmune thrombocytopenia |
Lymphadenopathy |
Follicular hyperplasia |
Splenomegaly |
Subacute progressive viral hepatitis |
Autoimmunity |
Recurrent infections |
Recurrent respiratory infections |
| Disease(s) Associated with NRAS | ||||||||||||||||||||||
| acute lymphoblastic leukemia | ||||||||||||||||||||||
| acute myeloid leukemia | ||||||||||||||||||||||
| autoimmune lymphoproliferative syndrome type 4 | ||||||||||||||||||||||
| hepatocellular carcinoma | ||||||||||||||||||||||
| multiple myeloma | ||||||||||||||||||||||
| Noonan syndrome 6 |
| Mouse Phenotypes | abnormal granulocyte differentiation |
abnormal thymus morphology |
enlarged spleen |
abnormal myelopoiesis |
myeloid hyperplasia |
increased neutrophil cell number |
increased granulocyte number |
abnormal leukocyte cell number |
increased T cell number |
decreased monocyte cell number |
increased monocyte cell number |
increased leukocyte cell number |
decreased spleen weight |
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| Availability | Mouse Genotype | |||||||||||||
| Nrastm1.1Emfu/Nrastm1.1Emfu | ||||||||||||||
| Nrastm1Tyj/Nrastm1Tyj Tg(Mx1-cre)1Cgn/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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